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receptor associated protein  (Sino Biological)


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    Structured Review

    Sino Biological receptor associated protein
    Receptor Associated Protein, supplied by Sino Biological, used in various techniques. Bioz Stars score: 94/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/receptor+associated+protein/Mouse+LRPAP1+%2F+RAP+Protein/pmc12407559-42-28-36
    Average 94 stars, based on 5 article reviews
    receptor associated protein - by Bioz Stars, 2026-09
    94/100 stars

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    other:

    Article Title: CD44s-activated tPA/LRP1-NFκB pathway drives lamellipodia outgrowth in luminal-type breast cancer cells
    Article Snippet: Primary antibodies against CD44 (ab189524, Abcam, Cambridge, UK), tPA (10147-1-AP, Proteintech, Chicago, United States), cortactin (ab81208, Abcam), p-Akt (4,060, CST, Danvers, United States), Akt (4,691, CST), β-actin (3,700, CST), LDL receptor related protein 1 (LRP1, BM4098, Boster, Wuhan, China), p-p65 (3,033, CST), p65 (8,242, CST), and inhibitors LY294002 (S1105, Selleck, Texas, United States), receptor associated protein (RAP, 11,100-H08H, Sino Biological, Beijing, China), LCKLSL (HY-P2333A, MCE, New Jersey, United States), AG1478 (153,436-53-4, MCE), BAY 11-7082 (HY-13453, MCE) were used.

    Blocking Assay:

    Article Title: Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway
    Article Snippet: .. Different inhibitors dissolved in culture medium were applied to block specific domains: 300 nM GGACK (34618, Cayman Chemical Company, MI, USA) to block the protease domain, 500 nM receptor-associated protein (RAP; an inhibitor of LRP; 50281- M08H, Sino Biological, Beijing, China) to block the effect of the finger domain, 5 μM AG-1478 (an inhibitor of the EGF receptor; HY13524-10, MCE, Shanghai, China) to block the function of EGF domain, and 300 nM tranexamic acid (TXA; HY-B0149-5, MCE) to block a target on the Kringle domain (n = 3/group). .. Specific pathogen-free C57BL/6J mice were provided by the Experimental Animal Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, China; Animal License No. SCXK (E) 2021-0009).

    Article Title: Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway
    Article Snippet: .. Different inhibitors dissolved in culture medium were applied to block specific domains: 300 nM GGACK (34618, Cayman Chemical Company, MI, USA) to block the protease domain, 500 nM receptor-associated protein (RAP; an inhibitor of LRP; 50281-M08H, Sino Biological, Beijing, China) to block the effect of the finger domain, 5 μM AG-1478 (an inhibitor of the EGF receptor; HY13524-10, MCE, Shanghai, China) to block the function of EGF domain, and 300 nM tranexamic acid (TXA; HY-B0149-5, MCE) to block a target on the Kringle domain ( n = 3/group). .. Specific pathogen-free C57BL/6J mice were provided by the Experimental Animal Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, China; Animal License No. SCXK (E) 2021-0009).



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    MDK upregulated LRP1 to improve efferocytosis through the PDI-ADAM17 axis. A: Bone marrow-derived macrophages (BMDMs) were treated with LPS (1 μg/mL) for 12 h. Apoptotic neutrophils (green) were added to BMDMs, with or without rMDK (200 ng/mL) for 12 h. LRPAP (50 μmol/L) was applied 0.5 h before rMDK. Confocal microscopy was used to quantify the phagocytosis index. Scale bars, 50 μm. B–D: LRP1 protein levels in RAW264.7 cells. Cells were treated with LPS (1 μg/mL) for 0, 3, 6, 12, 24 h (B), with LPS (1 μg/mL) for 24 h and rMDK for 3, 6, 12, 24 h (C), or with LPS (1 μg/mL) for 24 h with or without rMDK (200 ng/mL) for 12 h (D). E: LRP1 protein levels in the wound model. F and G: Lrp1 mRNA (F) and p-ADAM17 protein (G) levels in RAW264.7 cells treated as in (D). H: PDI protein levels in the supernatant of RAW264.7 cell cultures. I and J: p-ADAM17 (I) and PDI (J) protein levels in the wound. K: PDI protein levels in the plasma. Protein and mRNA levels were analyzed by Western blotting and reverse transcription-quantitative PCR, respectively. All data are presented as mean ± standard error of the mean. * P < 0.05, ** P < 0.01, and *** P < 0.001 by one-way ANOVA followed by Tukey's multiple comparisons test (A–K). Abbreviations: LPS, lipopolysaccharide; LRP1, <t>LDL</t> <t>receptor-related</t> protein 1; LRPAP, LDL <t>receptor-related</t> <t>protein-associated</t> protein; ns, not significant; p-ADAM17, phospho-a disintegrin and metalloproteinase domain-containing protein 17; PDI, protein disulfide isomerase; rMDK, recombinant midkine; rNMES, remote neuromuscular electrical stimulation.
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    MDK upregulated LRP1 to improve efferocytosis through the PDI-ADAM17 axis. A: Bone marrow-derived macrophages (BMDMs) were treated with LPS (1 μg/mL) for 12 h. Apoptotic neutrophils (green) were added to BMDMs, with or without rMDK (200 ng/mL) for 12 h. LRPAP (50 μmol/L) was applied 0.5 h before rMDK. Confocal microscopy was used to quantify the phagocytosis index. Scale bars, 50 μm. B–D: LRP1 protein levels in RAW264.7 cells. Cells were treated with LPS (1 μg/mL) for 0, 3, 6, 12, 24 h (B), with LPS (1 μg/mL) for 24 h and rMDK for 3, 6, 12, 24 h (C), or with LPS (1 μg/mL) for 24 h with or without rMDK (200 ng/mL) for 12 h (D). E: LRP1 protein levels in the wound model. F and G: Lrp1 mRNA (F) and p-ADAM17 protein (G) levels in RAW264.7 cells treated as in (D). H: PDI protein levels in the supernatant of RAW264.7 cell cultures. I and J: p-ADAM17 (I) and PDI (J) protein levels in the wound. K: PDI protein levels in the plasma. Protein and mRNA levels were analyzed by Western blotting and reverse transcription-quantitative PCR, respectively. All data are presented as mean ± standard error of the mean. * P < 0.05, ** P < 0.01, and *** P < 0.001 by one-way ANOVA followed by Tukey's multiple comparisons test (A–K). Abbreviations: LPS, lipopolysaccharide; LRP1, LDL receptor-related protein 1; LRPAP, LDL receptor-related protein-associated protein; ns, not significant; p-ADAM17, phospho-a disintegrin and metalloproteinase domain-containing protein 17; PDI, protein disulfide isomerase; rMDK, recombinant midkine; rNMES, remote neuromuscular electrical stimulation.

    Journal: Journal of Biomedical Research

    Article Title: Remote neuromuscular electrical stimulation upregulates MDK to enhance macrophage efferocytosis via LRP1 in wound healing

    doi: 10.7555/JBR.38.20240375

    Figure Lengend Snippet: MDK upregulated LRP1 to improve efferocytosis through the PDI-ADAM17 axis. A: Bone marrow-derived macrophages (BMDMs) were treated with LPS (1 μg/mL) for 12 h. Apoptotic neutrophils (green) were added to BMDMs, with or without rMDK (200 ng/mL) for 12 h. LRPAP (50 μmol/L) was applied 0.5 h before rMDK. Confocal microscopy was used to quantify the phagocytosis index. Scale bars, 50 μm. B–D: LRP1 protein levels in RAW264.7 cells. Cells were treated with LPS (1 μg/mL) for 0, 3, 6, 12, 24 h (B), with LPS (1 μg/mL) for 24 h and rMDK for 3, 6, 12, 24 h (C), or with LPS (1 μg/mL) for 24 h with or without rMDK (200 ng/mL) for 12 h (D). E: LRP1 protein levels in the wound model. F and G: Lrp1 mRNA (F) and p-ADAM17 protein (G) levels in RAW264.7 cells treated as in (D). H: PDI protein levels in the supernatant of RAW264.7 cell cultures. I and J: p-ADAM17 (I) and PDI (J) protein levels in the wound. K: PDI protein levels in the plasma. Protein and mRNA levels were analyzed by Western blotting and reverse transcription-quantitative PCR, respectively. All data are presented as mean ± standard error of the mean. * P < 0.05, ** P < 0.01, and *** P < 0.001 by one-way ANOVA followed by Tukey's multiple comparisons test (A–K). Abbreviations: LPS, lipopolysaccharide; LRP1, LDL receptor-related protein 1; LRPAP, LDL receptor-related protein-associated protein; ns, not significant; p-ADAM17, phospho-a disintegrin and metalloproteinase domain-containing protein 17; PDI, protein disulfide isomerase; rMDK, recombinant midkine; rNMES, remote neuromuscular electrical stimulation.

    Article Snippet: LDL receptor-related protein-associated protein (LRPAP; Cat. #HY-P76478A, MedChemExpress, Monmouth Junction, NJ, USA) was used as an LRP1 inhibitor.

    Techniques: Derivative Assay, Confocal Microscopy, Clinical Proteomics, Western Blot, Reverse Transcription, Real-time Polymerase Chain Reaction, Recombinant

    A schematic diagram showing the mechanism of rNMES in wound healing. rNMES induces MDK production in skeletal muscles through the AMPK-ERK axis. The secreted MDK then reaches the wound via blood circulation, enhances LRP1-mediated efferocytosis, and accelerates wound healing. Abbreviations: MDK, midkine; LRP1, low-density lipoprotein receptor-related protein 1; sLRP1, soluble LRP1; p-ADAM17, phospho-a disintegrin and metalloproteinase domain-containing protein 17; PDI, protein disulfide isomerase; p-AMPK, phospho-AMP-activated protein kinase; p-ERK, phospho-extracellular signal-regulated kinase; PMN, polymorphonuclear neutrophil; RBC, red blood cell; rNMES, remote neuromuscular electrical stimulation; NETs, neutrophil extracellular traps; ACs, apoptotic cells; E. coli , Escherichia coli .

    Journal: Journal of Biomedical Research

    Article Title: Remote neuromuscular electrical stimulation upregulates MDK to enhance macrophage efferocytosis via LRP1 in wound healing

    doi: 10.7555/JBR.38.20240375

    Figure Lengend Snippet: A schematic diagram showing the mechanism of rNMES in wound healing. rNMES induces MDK production in skeletal muscles through the AMPK-ERK axis. The secreted MDK then reaches the wound via blood circulation, enhances LRP1-mediated efferocytosis, and accelerates wound healing. Abbreviations: MDK, midkine; LRP1, low-density lipoprotein receptor-related protein 1; sLRP1, soluble LRP1; p-ADAM17, phospho-a disintegrin and metalloproteinase domain-containing protein 17; PDI, protein disulfide isomerase; p-AMPK, phospho-AMP-activated protein kinase; p-ERK, phospho-extracellular signal-regulated kinase; PMN, polymorphonuclear neutrophil; RBC, red blood cell; rNMES, remote neuromuscular electrical stimulation; NETs, neutrophil extracellular traps; ACs, apoptotic cells; E. coli , Escherichia coli .

    Article Snippet: LDL receptor-related protein-associated protein (LRPAP; Cat. #HY-P76478A, MedChemExpress, Monmouth Junction, NJ, USA) was used as an LRP1 inhibitor.

    Techniques: Muscles